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The Human Endocannabinoid System (ECS)

Scientists have conducted research on the Human Endocannabinoid System (ECS) yet they have only begun to understand its significance. It may just be the most important discovery during the late 20th century. 

human endocannabinoid system

In fact, it’s connected to the rise in popularity of CBD products. More products such as oil tinctures, topicals, and capsules have become trendy. Consumers now use them for many health conditions such as arthritis, migraines, and anxiety.

As experts discover more health benefits of the cannabis plant, more of these were linked to the endocannabinoid receptors. The plant cannabinoids in CBD products provide alternative remedies to several medical conditions.

Studies have found that the ECS controls and maintains homeostasis in the human body. This means it regulates balance throughout the body’s systems. It is able to do so through its known CB1 and CB2 receptors.

The two kinds of receptors are located in particular parts of the body. The location will determine the effects the receptors will induce. In addition, cannabinoids will cause certain effects.

What is the ECS?

This is a control system in every animal that relies on certain cannabinoids to perform specific biological functions. These will depend on the cannabinoid it receives, much like how a key opens a particular lock. It consists of neuromodulatory lipids, including fats, sterols, and waxes. It also includes some fat-soluble vitamins, such as vitamins A, D, E, and K.

In addition, it has specialized receptors located throughout the body that receives the cannabinoids that trigger it. The receptors modulate the signal it sends to neighboring cells, the activity of other cells, and/or the regulation of genes. These functions are dependent on the location of the receptors. This entire process of endocannabinoid signaling is signal transduction.

These receptors are all throughout the body, especially in the central nervous system and peripheral nervous system. There, the endocannabinoids mediate neuron activity. 

These are spread in the cerebral cortex, hippocampus, cerebellum, and the hypothalamus. These are in charge of your decision-making, memory, motor control, and appetite respectively. Moreover, the receptors are also in the putamen and the amygdala. The putamen is in charge of your learning and movement while the amygdala regulates your emotions.

In addition, the human endocannabinoid system regulates body temperature using a specific receptor. This specialized receptor called the transient receptor potential vanilloid-type one (TRPV1). Moreover, it is responsible for feeling extreme external heat and pain. 

Endocannabinoid Production in the Human Body

The main function of the ECS is to maintain bodily homeostasis. 

cb1 receptors

Initial research conducted on the ECS concluded that the receptors could only be located in the brain and the nerves. However, with more tests and updated material, scientists later found that these receptors can be located throughout the body.

Scientists now claim that endocannabinoid receptors can be located in the skin, bones, fat, tissue, liver, pancreas, heart, and kidney, to name a few places. 

The ECS is responsible for a host of processes within the body. These processes range from pain, memory, mood, appetite, stress, sleep, and immune function. Within the body, the endocannabinoid system is one of the most widespread and versatile signaling molecules known. 

How it Works

There are three main components that make up the endocannabinoid system: endocannabinoids, receptors, and enzymes.

First, are endocannabinoids. Some scientific literature also refer to this compound as the “endogenous cannabinoid.” This type of molecule naturally occurs in the system. There are two key endocannabinoids in the ECS: anandamide (AEA) and arachidonoylglycerol (2-AG). These two compounds keep the internal functions of the body functioning.

The second key component of the ECS are receptors. These molecules are located throughout the body. Endocannabinoids bind receptors together to signal the ECS to take action. There are two main receptors that endocannabinoids bind to CB1 receptors and CB2 receptors. The former is located in the central nervous system, while the latter is located in the peripheral nervous system, especially in immune cells. 

The effects of the bond between endocannabinoids and receptors depend on the location of the receptor and what endocannabinoid it binds to. The possible and various health benefits produced by these bonds include pain relief, reduction of inflammation, and more. 

The third key component of the ECS is enzymes. Enzymes are responsible for breaking down endocannabinoids after they have carried out their functions.

CB1 receptor

The CB1 and CB2 receptors make up most of the endocannabinoid system. Each type of receptor performs roles unique to each other.

First, the CB1 receptors are found in many organs, glands, gonads, and connective tissues. These receptors serve important functions in motivation, movement coordination, sensory perceptions, spatial orientation, and cognitive performance. This may be why they aren’t in the medulla oblongata, the part of the brain responsible for cardiovascular and respiratory functions.

ecs receptors and cbd

The CB1 cannabinoid receptors also help reduce the exceeding or lacking signaling by the neurotransmitters in the brain. In fact, the excess of such signals causes pain in several areas of the body. When a cannabinoid such as THC is applied, the signals may be minimized, lessening pain. Also, CB1 receptor antagonists like CBD can have properties akin to antipsychotic drugs.

Although experts found CB1-R in the brain first, recent studies show the presence of CB1-R in other parts of the body. This includes many other organs, tissues, and glands. 

The main function of the CB1-R is limiting the movement of neurotransmitters in the brain. The interaction of CBD and CB1-R regulates the activity of neurotransmitters and brings them back to balance.

When the THC compound binds to CB1-R, it inhibits activity in the pain receptors. It can also dull other sensations such as nausea, seizure episodes, and muscle spasms. These are just some of the benefits of cannabinoid therapy. 

CB2 receptors

The CB2 receptors are mainly associated with the immune system and its immune cells. They are also in regions outside the brain such as the lymph cells, blood vessels, bones, kidneys, heart, kidneys, spleen, and the liver. 

Back then, scientists believed these receptors to have no role concerning nerve cells. Now, recent studies report that it plays a vital role in the brain’s signaling system.

Omega-3 Deficiencies

Omega-3 cannot be produced by the human body. A person’s Omega-3 intake is a result of the food that they consume that contain Omega-3. However, not all food contain sufficient enough amounts of Omega-3 to satisfy the body’s need for this compound.

Omega-3 Deficiencies

A deficiency in Omega-3 can cause dry skin, poor concentration, joint pain, weight gain, and eyesight issues. This compound is also responsible for the building up of cell walls which is essential for a variety of processes in the body.

Some people tweak their diets to consume more Omega-3 to address their deficiency issues. However, some people prefer to take Omega-3 supplements that are easy to ingest and integrate into their everyday lifestyle.

Endocannabinoid Deficiency Syndrome

It is possible to trace illnesses rooted in the immune system or inflammation to an endocannabinoid deficiency.

This deficiency occurs when the ECS is not functioning to its highest ability, either because of a lack of endocannabinoids or receptors. When the endocannabinoid system does not function correctly, other processes in the body are not regulated and the overall body becomes unbalanced. An unbalanced system leaves the body vulnerable to different diseases. 

Currently, there are different kinds of dietary supplements available in the market that can help people decrease their chances of developing an endocannabinoid deficiency. 

Treatment Options

For people suffering from an Omega-3 deficiency, there are many options available to them to address their issues. Doctors recommend changing dietary habits to include food that is high in Omega-3 like fish, nuts, and fortified food. 

Treatment Options

Supplements like cannabidiol, or CBD, may also prove helpful to people with deficiencies. CBD can prevent endocannabinoids from breaking down. Some cannabidiol products also contain traces of THC which may also bind to receptors like endocannabinoids.

Studies have shown that hemp supplements can help with both Omega-3 deficiencies and endocannabinoid deficiency syndrome. 

Learn More About CBD

One of the many compounds found in the cannabis sativa plant or hemp plant is cannabidiol. In recent years, this compound has seen a meteoric rise in popularity. Due to the increase of interest in this compound, scientists have conducted a wide range of tests on CBD. 

Studies show that CBD does most of its work within the endocannabinoid system. The most quoted positive side-effect of CBD is its ability to reduce pain in users. Research shows that this anti-inflammatory effect occurs due a peripheral reaction between cannabidiol and the receptors in the ECS. 

In a survey conducted to gauge the effects of cannabidiol, 90% of the participants claimed that using CBD products has helped reduce the frequency and duration of their pain episodes. Similarly, 70% claimed that CBD helped make the severity of the pain they felt more bearable. 

There has also been scientific research conducted on cannabidiol’s potential to combat anxiety. Since the ECS also has a hand in mood regulation in the body, the compound’s interaction with ECS receptors may also aid in combating general anxiety disorders. 

Even though the research on cannabidiol is in its preliminary stages, the results show that this hemp compound has many promising attributes.

CBD and the ECS

Cannabidiol helps people curb their cannabinoid deficiency. Such substances are needed by the human endocannabinoid system to function. A lack of them causes the system to perform suboptimally, causing a decline in one’s general health.

The human endocannabinoid system has receptors that are activated by the three types of cannabinoids: endocannabinoids, phytocannabinoids, and synthetically-produced cannabinoids. CBD and THC are phytocannabinoids, so taking products that have them will maintain your endocannabinoid system’s performance.

CBD Health Benefits

The growing number of studies regarding the human endocannabinoid system has revealed the many health benefits of cannabidiol.

This has led to the creation of various CBD products for sale that provide substitutes for conventional treatments. These include oil tinctures, capsules,  and even gummies.

Pain Relief

People have used cannabidiol for pain relief for thousands of years, making it one of the main reasons why people look to CBD products. Cannabidiol has pain relief properties, helping with joint pains, headaches, and migraines

Pain Relief

Another reason why people use CBD products is that they are an alternative that poses little risk of side effects. In contrast, many drugs that can be bought over the counter have well-known side effects.

CBD products have mundane and improbable side effects, and they also have no long-term effects.

Heart Health

As mentioned earlier, the ECS deals with homeostasis, and it includes the regulation of blood pressure. CBD can actually help lower blood pressure and promote cardiovascular health.

For instance, CBD can decrease the inflammation in the blood vessels of animals. A study reported that 600 mg of CBD reduced the blood pressure of human participants during high levels of stress.

These findings are still inconclusive as they aren’t enough to prove the effectiveness of CBD. Nevertheless, CBD is still a potential way to maintain heart health.

Sleeping Aid

There are trials aimed at finding out the effects of CBD on peoples’ sleep. Some studies have discovered that 15 mg of CBD can help people fall asleep. However, some studies show the opposite to be true. Research suggests that increasing the dose may have a stimulating effect, making it difficult to sleep.

cbd oil

Moreover, CBD may help people forget their dreams. Studies have found lesser dream recall among participants. This can be a relief for those suffering from night terrors.

Again, further study is needed to confirm how CBD can help people sleep. Nevertheless, cannabidiol still is promising for many scientists.

Focus Aid

Anxiety also affects peoples’ ability to focus. Cannabidiol also helps increase a person’s serotonin levels which relieve anxiety in turn. In fact, a study found that approximately 50 mg of CBD may help.

Still, more research and trials are necessary to prove and even enhance these effects of CBD on focus and concentration. Perhaps it may become a staple in sharpening one’s concentration in the future.


The human endocannabinoid system benefits greatly from cannabidiol. The ECS regulates the body’s vital functions, and the cannabis extract maintains its peak performance. Cannabinoids activate certain receptors and trigger specific functions. This produces various health effects as a result.

The many effects led more people to purchase and use more CBD products. This then caused their popularity, encouraging people to make more variants of CBD products. These include topicals, oil tinctures, and gummies.

Nevertheless, continued research is necessary to test this hemp compound’s possible effects. More trials may lead to enhancing the health effects of CBD, perhaps even finding new effects.

Your endocannabinoid system may be lacking cannabidiol deficiency, meaning your health may not be at its peak. To alleviate this, you may want to take phytocannabinoids such as THC and CBD.

This is why you should head to Blosum for the best CBD products. To ensure customers of the purity of their products, Blosum third-party lab tests all their products. In the same vein, this hemp company only uses hemp grown in the United States. When you want to increase your cannabidiol levels, choose Blosum.

Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Keep in mind that nonprescription CBD products are not FDA-approved, and maybe inaccurately labeled.

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