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The Human Endocannabinoid System (ECS)

Scientists have conducted research on the Human Endocannabinoid System (ECS) yet they have only begun to understand its significance. It may just be the most important discovery during the late 20th century. 

human endocannabinoid system

In fact, it’s connected to the rise in popularity of CBD products. More products such as oil tinctures, topicals, and capsules have become trendy. Consumers now use them for many health conditions such as arthritis, migraines, and anxiety.

As experts discover more health benefits of the cannabis plant, more of these were linked to the endocannabinoid receptors. The plant cannabinoids in CBD products provide alternative remedies to several medical conditions.

Studies have found that the ECS controls and maintains homeostasis in the human body. This means it regulates balance throughout the body’s systems. It is able to do so through its known CB1 and CB2 receptors.

The two kinds of receptors are located in particular parts of the body. The location will determine the effects the receptors will induce. In addition, cannabinoids will cause certain effects.

What is the ECS?

This is a control system in every animal that relies on certain cannabinoids to perform specific biological functions. These will depend on the cannabinoid it receives, much like how a key opens a particular lock. It consists of neuromodulatory lipids, including fats, sterols, and waxes. It also includes some fat-soluble vitamins, such as vitamins A, D, E, and K.

cb1 receptors

In addition, it has specialized receptors located throughout the body that receives the cannabinoids that trigger it. The receptors modulate the signal it sends to neighboring cells, the activity of other cells, and/or the regulation of genes. These functions are dependent on the location of the receptors. This entire process of endocannabinoid signaling is signal transduction.

These receptors are all throughout the body, especially in the central nervous system and peripheral nervous system. There, the endocannabinoids mediate neuron activity. 

These are spread in the cerebral cortex, hippocampus, cerebellum, and the hypothalamus. These are in charge of your decision-making, memory, motor control, and appetite respectively. Moreover, the receptors are also in the putamen and the amygdala. The putamen is in charge of your learning and movement while the amygdala regulates your emotions.

In addition, the human endocannabinoid system regulates body temperature using a specific receptor. This specialized receptor called the transient receptor potential vanilloid-type one (TRPV1). Moreover, it is responsible for feeling extreme external heat and pain. 

CB1 receptor

The CB1 and CB2 receptors make up most of the endocannabinoid system. Each type of receptor performs roles unique to each other.

First, the CB1 receptors are found in many organs, glands, gonads, and connective tissues. These receptors serve important functions in motivation, movement coordination, sensory perceptions, spatial orientation, and cognitive performance. This may be why they aren’t in the medulla oblongata, the part of the brain responsible for cardiovascular and respiratory functions.

ecs receptors and cbd

The CB1 cannabinoid receptors also help reduce the exceeding or lacking signaling by the neurotransmitters in the brain. In fact, the excess of such signals causes pain in several areas of the body. When a cannabinoid such as THC is applied, the signals may be minimized, lessening pain. Also, CB1 receptor antagonists like CBD can have properties akin to antipsychotic drugs.

Although experts found CB1-R in the brain first, recent studies show the presence of CB1-R in other parts of the body. This includes many other organs, tissues, and glands. 

The main function of the CB1-R is limiting the movement of neurotransmitters in the brain. The interaction of CBD and CB1-R regulates the activity of neurotransmitters and brings them back to balance.

When the THC compound binds to CB1-R, it inhibits activity in the pain receptors. It can also dull other sensations such as nausea, seizure episodes, and muscle spasms. These are just some of the benefits of cannabinoid therapy. 

CB2 receptors

The CB2 receptors are mainly associated with the immune system and its immune cells. They are also in regions outside the brain such as the lymph cells, blood vessels, bones, kidneys, heart, kidneys, spleen, and the liver. 

Back then, scientists believed these receptors to have no role concerning nerve cells. Now, recent studies report that it plays a vital role in the brain’s signaling system.

CBD and the ECS

Cannabidiol helps people curb their cannabinoid deficiency. Such substances are needed by the human endocannabinoid system to function. A lack of them causes the system to perform suboptimally, causing a decline in one’s general health.

The human endocannabinoid system has receptors that are activated by the three types of cannabinoids: endocannabinoids, phytocannabinoids, and synthetically-produced cannabinoids. CBD and THC are phytocannabinoids, so taking products that have them will maintain your endocannabinoid system’s performance.

CBD Health Benefits

The growing number of studies regarding the human endocannabinoid system has revealed the many health benefits of cannabidiol. This has led to the creation of various CBD products for sale that provide substitutes for conventional treatments. These include oil tinctures, capsules,  and even gummies.

Pain Relief

cbd for pain

People have used cannabidiol for pain relief for thousands of years, making it one of the main reasons why people look to CBD products. Cannabidiol has pain relief properties, helping with joint pains, headaches, and migraines

Another reason why people use CBD products is that they are an alternative that poses little risk of side effects. In contrast, many drugs that can be bought over the counter have well-known side effects.

CBD products have mundane and improbable side effects, and they also have no long-term effects.

Heart Health

As mentioned earlier, the ECS deals with homeostasis, and it includes the regulation of blood pressure. CBD can actually help lower blood pressure and promote cardiovascular health.

For instance, CBD can decrease the inflammation in the blood vessels of animals. A study reported that 600 mg of CBD reduced the blood pressure of human participants during high levels of stress.

These findings are still inconclusive as they aren’t enough to prove the effectiveness of CBD. Nevertheless, CBD is still a potential way to maintain heart health.

Sleeping Aid

There are trials aimed at finding out the effects of CBD on peoples’ sleep. Some studies have discovered that 15 mg of CBD can help people fall asleep. However, some studies show the opposite to be true. Research suggests that increasing the dose may have a stimulating effect, making it difficult to sleep.

Moreover, CBD may help people forget their dreams. Studies have found lesser dream recall among participants. This can be a relief for those suffering from night terrors.

Again, further study is needed to confirm how CBD can help people sleep. Nevertheless, cannabidiol still is promising for many scientists.

Focus Aid

cbd oil

Anxiety also affects peoples’ ability to focus. Cannabidiol also helps increase a person’s serotonin levels which relieve anxiety in turn. In fact, a study found that approximately 50 mg of CBD may help.

Still, more research and trials are necessary to prove and even enhance these effects of CBD on focus and concentration. Perhaps it may become a staple in sharpening one’s concentration in the future.


The human endocannabinoid system benefits greatly from cannabidiol. The ECS regulates the body’s vital functions, and the cannabis extract maintains its peak performance. Cannabinoids activate certain receptors and trigger specific functions. This produces various health effects as a result.

The many effects led more people to purchase and use more CBD products. This then caused their popularity, encouraging people to make more variants of CBD products. These include topicals, oil tinctures, and gummies.

Nevertheless, further research and study are needed to confirm its effects. More trials may lead to enhancing the health effects of CBD, perhaps even finding new effects.

Your endocannabinoid system may be lacking cannabidiol deficiency, meaning your health may not be at its peak. To alleviate this, you may want to take phytocannabinoids such as THC and CBD.

This is why you should head to Blosum for the best CBD products. Their products are made with the best, high-quality CBD oil that is guaranteed lab-tested and USA-grown. When you want to increase your cannabidiol levels, choose Blosum.

Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Keep in mind that nonprescription CBD products are not FDA-approved, and maybe inaccurately labeled.

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