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What is Cannabidiolic Acid (CBDA)?

The cannabis plant has many naturally occurring chemical compounds. One of them is cannabidiol (CBD). From the CBD compound comes cannabidiolic acid (CBDA).

Most times, scientists consider CBDA to be the parent molecule of CBD. Consequently, CBD and CBDA have many similiarities. Canabidiodibic acid convert to cannabidiol through decarboxylation or decarbing.

Cannabidiolic Acid, cbda, cbd products

Scientists have many names for CBDA, one of them being carboxylic acid. As a result, its molecular structure contains a carboxyl group. This group comprises of one carbon, one hydrogen, and two oxygen atoms. In addition, exposure to high temperatures makes this group break down, causing the formation of carbon dioxide and hydrogen. This breaking down process reduces it to cannabidiol (CBD).

Raw cannabis (unheated and uncured) contains CBDA. Furthermore, this means that it has a high concentration of tetrahydrocannabinol (THC). From fresh cannabis, 95 percent of cannabinoids exist as THC and only 5 percent as CBD.

How does Cannabidiolic Acid Work?

Researchers discovered that CBDA does not cause a psychoactive high. For CBDA to be extracted, raw cannabis plants must be kept in its raw form for a while until they brim with CBDA. Cannabidiolic acid can also be extracted from cannabis plants classified as hemp.

Although most cannabinoids bind directly with either the CB1 or CB2 receptors, CBDA does not work that way. 

It interacts with the endocannabinoid system by inhibiting the work of the cyclooxygenase-2 (COX-2) enzyme. These enzymes are associated with inflammation which occur after an injury or infection. By blocking the work of the COX-2 inhibitor, CBDA can help relieve inflammation and associated pain.

Benefits of Using CBDA

Although there is not a lot of published research on CBDA, scientists have purported that the benefits of cannabidiolic acid are promising.

Relief during inflammation 

Inflammation is a natural and important response to stress, illness, and/or injury. Sometimes, they may develop into chronic inflammation which is detrimental to the person’s health. 

A common example of a chronic inflammatory condition is arthritis. How CBDA works is by restricting the work of the COX-2 enzyme. It was more successful in relieving inflammatory pains than its counterpart which is the tetrahydrocannabinolic acid (THCA).


One of the conditions CBDA might help relieve is in the area of cancer. Cannabidiolic acid has shown potential in suppressing breast cancer cells, thereby inhibiting their constant spread throughout the body. Scientists call this process metastasis.

Nausea & vomiting

In addition to most research cases, CBDA is anti-nausea. It reduces the nausea behaviors in rodents. Studies discovered that CBDA is actually more powerful in the act of quieting an upset stomach.

Anxiety and psychotic disorders

Although there has been no grounded research on the use of CBDA in treating psychotic disorders, scientists believe that there is enough preclinical evidence that can potentially help in dealing with this.

Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.

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