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What is Cannabigerol (CBG)?

Cannabigerol (CBG) is one of the most important cannabinoids in existence. A cannabinoid is a chemical compound that is derived from the cannabis plant. 

cannabigerol cbg

They bind themselves with the receptors which are present in the body. By so doing, they cause different effects in the body. These effects may be therapeutic, psychoactive or both.

The two well-known cannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD does not give any psychoactive effects. It gives therapeutic effects while THC is the major psychoactive ingredient in cannabis.

A fact that is not well known is that cannabigerol (CBG) is often thought of as “the mother of all cannabinoids.” These cannabinoids include cannabidiol (CBD) tetrahydrocannabinol (THC), cannabinol (CBN), and cannabichromene (CBC).

It is essentially the building block on which the other cannabinoids depend on although it is often classified as a minor type of cannabinoid.

CBG 101

CBG is a non-psychoactive cannabinoid, found in both hemp and cannabis plants. It is often used for the treatment of multiple medical conditions, ailments, and diseases. It can also be found in lower concentration levels than THC and CBD.

CBG is non-acidic although it is often found in the form of cannabigerolic acid (CBGA). This acid is the major building block for the main branches of cannabinoids which are: 

Due to the decarboxylation process, CBGA loses a carbon group and becomes CBG and the same happens with the other acids and they become CBC, CBD, and THC respectively.

How Does CBG Work?

Like all other cannabinoids, CBG interacts with the body by binding itself with the endocannabinoid system (ECS) in the body. This system is a complex collection of cannabinoid receptors (CB1 and CB2 receptors), enzymes, and chemicals known as endocannabinoids.

CB1 receptors are primarily found in the brain and the nervous system and CB2 receptors are found in other parts of the body but primarily found in the immune system. The well-known endocannabinoids are arachidonoylglycerol (2-AG) and anandamide (AEA). 

the endocannabinoid system

AEA primarily binds with the CB1 receptors and it acts like a neurotransmitter that can affect the mood and cognitive functions such as learning, reasoning, decision making, attention, memory, etc. Similarly, 2-AG binds with the CB2 receptors and produces an anti-inflammatory effect on the body.

Cannabinoids can bind with these receptors in the same way because they have a similar structure to the endocannabinoids. THC binds with the CB1 receptors and this is why it can produce the psychoactive effects that it gives off. CBG primarily binds with the CB2 receptors and when they are present in large doses, they have the ability to block any other compounds from binding with the CB1 receptors. 

It has been observed that the usage of several cannabinoids at the same time produces what is known as the “entourage effect”. This effect suggests that it is medically beneficial to use these cannabinoids in combination rather than one of them alone.

Medical Benefits of CBG

Ranging from anti-inflammatory to analgesic effects, CBG has a wide range of health benefits. 

Pain reliever

CBG is a powerful pain reliever especially for patients with inflammatory bowel disease (IBD), chronic inflammation, and chronic pain. 

It can reduce contractions in the bladder induced by the action of acetylcholine. This is a chemical serving as a neurotransmitter for neurons, gland cells, and muscle cells.

Antibacterial agent

It also works as an antibacterial agent and an antimicrobial agent. They tested it against various strains of staphylococcus aureus bacteria and found it to have reduced the cells present. CBG can inhibit its growth.

Promotes better quality of sleep

One of its side effects is drowsiness, which makes it perfect as an anti-insomnia agent. It can improve sleep thanks to its therapeutic effects.


CBG can stimulate the appetite especially in people who suffer from eating disorders such as anorexia. 

Other than the appetite, it can stimulate bone growth. It also helps to promote neuron growth, making it a brain cell stimulant.

Fights cancer

It is an anti-proliferative or an anti-cancer agent which means that it inhibits the growth of cancerous cells present in the body. 

Some cells it can reduce are breast, leukemia, thyroid, prostate, glioma, gastric, and colorectal cancer cells. Researchers are hopeful for the use of CBG as a form of cancer treatment.

Reduces seizures

It is an anti-convulsive or anti-emetic agent that helps to reduce the number of convulsions or seizures that a person has.

Treats depression

It is an antidepressant and is useful for treating depression, anxiety, and increased stress levels. CBG blocks the uptake of the noradrenaline neurotransmitter by the brain cells.

Anti-oxidizing properties

It is thought to be an antioxidant that protects the nervous system from damage. It improves deficits in motor actions and promotes the preservation of the neurons in cases of neurodegenerative diseases.

Disorders CBG Can Treat

Aside from its medical benefits, CBG can potentially treat the following disorders.


CBG helps reduce intraocular pressure and in speeding up the fluid draining process in the eyes. 

Huntington’s disease

This is an inherited neurodegenerative disease that causes nerve cells present in the brain to break down over time. It is more common in people in their 30’s and 40’s.


This is a condition where the skin cells build up and form scales over time. This causes itchy, dry patches. 

Doctors theorize that a problem in the immune system causes psoriasis. Situations that include high stress can trigger it.


This is a condition where the bones become brittle and weak. Even though there is new bone creation, it does not keep up with the removal of the old bones.

Microbial strains which are resistant to methicillin such as staphylococcus aureus strain (MRSA). It is tougher to treat than most staphylococcus strains.

Side Effects of CBG

There are no known side effects of CBG if it is consumed in small or therapeutic doses unless you consume an excessive amount of 300 milligrams per kilogram of the body’s weight. 

This means that if a person weighs 180 pounds, the person would need to consume about 54,000 milligrams of CBG for it to become dangerous.

Methods of Consuming Cannabigerol 

A CBG isolate can be consumed by itself or it can be processed into another product for consumption. 


It can be turned into CBG gummies which can be consumed as snacks. This form of CBG edibles lets you get the benefits while having a tasty treat.

You can also ingest CBG sublingually by dissolving it under the tongue for rapid absorption into the bloodstream.

cbg cosmestics


Your skincare routine can also use CBG products. Brands are infusing CBG into everyday items like shampoos, conditioners, hand creams, deodorant sprays, and facial wash.

It’s a seamless way of incorporating CBG into your regimen without any hassle.


Medical cannabis as a whole is still undergoing further research. The Food and Drug Administration (FDA) has not approved the recreational use of CBG and CBD products, but many lawmakers are lobbying for the full legalization of marijuana and hemp strains.

Before using any CBG-infused products, check your state laws to see if it can be bought commercially. 

Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.

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